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  Indian J Med Microbiol
 

Figure 3: Quercetin induces HO-1 expression, and inhibits HMGB1 expression and the activation of the NLRP3 inflammasome in the retina of STZ-induced diabetic rats. (A) mRNA expression levels of HO-1, HMGB1, NLRP3, ASC and in the retina detected by real-time polymerase chain reaction. (B, C) Western blot analysis of HO-1, HMGB1 and NLRP3 inflammasome-related protein expression in the retina. Data are expressed as the mean ± SD (n = 10). *P < 0.05, **P < 0.01 (two-way analysis of variance followed by the Bonferroni multiple comparison test). ASC: Apoptosis associated speck-like protein containing a card; HMGB1: high-mobility group box 1; HO-1: heme oxygenase-1; NLRP3: NLR family, pyrin domain containing 3; Q: quercetin; STZ: streptozocin; Znpp: zinc protoporphyrin IX.

Figure 3: Quercetin induces HO-1 expression, and inhibits HMGB1 expression and the activation of the NLRP3 inflammasome in the retina of STZ-induced diabetic rats.
(A) mRNA expression levels of <i>HO-1</i>, <i>HMGB1</i>, <i>NLRP3</i>, <i>ASC</i> and in the retina detected by real-time polymerase chain reaction. (B, C) Western blot analysis of HO-1, HMGB1 and NLRP3 inflammasome-related protein expression in the retina. Data are expressed as the mean ± SD (<i>n</i> = 10). *<i>P</i> < 0.05, **<i>P</i> < 0.01 (two-way analysis of variance followed by the Bonferroni multiple comparison test). ASC: Apoptosis associated speck-like protein containing a card; HMGB1: high-mobility group box 1; HO-1: heme oxygenase-1; NLRP3: NLR family, pyrin domain containing 3; Q: quercetin; STZ: streptozocin; Znpp: zinc protoporphyrin IX.