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  Indian J Med Microbiol
 

Figure 2: Effects of H2S on dopaminergic neurons in Parkinson’s disease mouse model. (A) Immunohistochemical staining of TH-positive neurons (green, stained by fluorescein isothiocyanate; original magnification 10×, scare bar: 40 μm). (B) Quantitative results of TH-positive neurons in the substantia nigra pars compacta (SNc). Data are expressed as mean ± SEM (n = 6). ***P < 0.001, vs. saline group; ###P < 0.001, vs. MPTP group (one-way analysis of variance followed by Tukey’s post hoc test). All samples were detected repeatedly in three independent experiments. DAPI: 4′,6-Diamidino-2-phenylindole, blue; H2S: hydrogen sulfide; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NaHS: sodium hydrosulfide a donor of H2S; TH: tyrosine hydroxylase.

Figure 2: Effects of H<sub>2</sub>S on dopaminergic neurons in Parkinson’s disease mouse model.
(A) Immunohistochemical staining of TH-positive neurons (green, stained by fluorescein isothiocyanate; original magnification 10×, scare bar: 40 μm). (B) Quantitative results of TH-positive neurons in the substantia nigra pars compacta (SNc). Data are expressed as mean ± SEM (<i>n</i> = 6). ***<i>P</i> < 0.001, <i>vs</i>. saline group; ###<i>P</i> < 0.001, <i>vs</i>. MPTP group (one-way analysis of variance followed by Tukey’s <i>post hoc</i> test). All samples were detected repeatedly in three independent experiments. DAPI: 4′,6-Diamidino-2-phenylindole, blue; H<sub>2</sub>S: hydrogen sulfide; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NaHS: sodium hydrosulfide a donor of H<sub>2</sub>S; TH: tyrosine hydroxylase.