Figure 2: Anti-hyperalgesic effects of PPX during reserpine model. Animals received PPX (0.1, 1 and 5 mg/kg, intraperitoneally) or vehicle after reserpine administration and submitted to von Frey test aiming to evaluate mechanical allodynia (A) and area under the curve (B). Mechanical hypersensitivity was evaluated before (baseline) and at the 3rd, 4th, 9th, and 14th days after reserpine injection (0.25 mg/kg, subcutaneously). Each line/column represents the mean ± SEM of nine to eleven mice/group and are representative of two independent experiments (ntotal = 18–22 mice/group). *P < 0.05, **P < 0.01, vs. reserpine group; ##P < 0.01, vs. vehicle group (two-way analysis of variance followed by Bonferroni’s post hoc test). AUC: Area under the curve; PPX: pramipexole.