Figure 3: Antinociceptive effects of PPX in reserpinized mice. Effects of therapeutic treatment with PPX (0.1, 1 and 5 mg/kg, intraperitoneally) were measured through the tail-flick test on the 3rd, 4th, 9th, and 14th days after reserpine administration (0.25 mg/kg, subcutaneously). Each column represents the mean ± SEM of nine to eleven mice/group and are representative of two independent experiments (ntotal = 18–22 mice/group). *P < 0.05, **P < 0.01, vs. reserpine group; #P < 0.05, ##P < 0.001, vs. vehicle group (one-way analysis of variance followed by Newman-Keuls post hoc test). PPX: Pramipexole.