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  Indian J Med Microbiol
 

Figure 6: Effects of preventive PPX treatment in reserpinized mice. PPX (0.1, 1 and 5 mg/kg, intraperitoneally) or pregabalin (30 mg/kg, oral route) were administered during 4 days on behavioral tests in mice: mechanical hyperalgesia (A), area under the curve (AUC; B), thermal hyperalgesia (C), and body weight (D) after reserpine administration (0.25 mg/kg, subcutaneously). Each line/column represents the mean ± SEM of six mice/group and are representative of two independent experiments (ntotal = 12 mice/group). *P < 0.05 and **P < 0.01, vs. reserpine group; ##P < 0.01, vs. vehicle group; ΔΔP < 0.01 (A: two-way analysis of variance followed by Bonferroni’s post hoc test; B–D: one-way analysis of variance followed by Newman-Keuls post hoc test). PPX: Pramipexole.

Figure 6: Effects of preventive PPX treatment in reserpinized mice.
PPX (0.1, 1 and 5 mg/kg, intraperitoneally) or pregabalin (30 mg/kg, oral route) were administered during 4 days on behavioral tests in mice: mechanical hyperalgesia (A), area under the curve (AUC; B), thermal hyperalgesia (C), and body weight (D) after reserpine administration (0.25 mg/kg, subcutaneously). Each line/column represents the mean ± SEM of six mice/group and are representative of two independent experiments (<i>n</i><sub>total</sub> = 12 mice/group). *<i>P</i> < 0.05 and **<i>P</i> < 0.01, <i>vs</i>. reserpine group; ##<i>P</i> < 0.01, <i>vs</i>. vehicle group; ΔΔ<i>P</i> < 0.01 (A: two-way analysis of variance followed by Bonferroni’s <i>post hoc</i> test; B–D: one-way analysis of variance followed by Newman-Keuls <i>post hoc</i> test). PPX: Pramipexole.