Figure 6: Effects of preventive PPX treatment in reserpinized mice. PPX (0.1, 1 and 5 mg/kg, intraperitoneally) or pregabalin (30 mg/kg, oral route) were administered during 4 days on behavioral tests in mice: mechanical hyperalgesia (A), area under the curve (AUC; B), thermal hyperalgesia (C), and body weight (D) after reserpine administration (0.25 mg/kg, subcutaneously). Each line/column represents the mean ± SEM of six mice/group and are representative of two independent experiments (ntotal = 12 mice/group). *P < 0.05 and **P < 0.01, vs. reserpine group; ##P < 0.01, vs. vehicle group; ΔΔP < 0.01 (A: two-way analysis of variance followed by Bonferroni’s post hoc test; B–D: one-way analysis of variance followed by Newman-Keuls post hoc test). PPX: Pramipexole.