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  Indian J Med Microbiol
 

Figure 1: Region-specific effects of serotonergic signaling on adult neurogenesis. (A) Scheme of the mouse head showing the location of the nasal cavity, olfactory epithelium, olfactory bulb (OB), and the cortex. (B) Magnification of the area, delineated by the broken line in A, showing olfactory sensory neurons (OSNs, orange) within the olfactory epithelium projecting to the OB and terminating in the glomeruli. Adult-born cells (green) arrive in the OB after migration along the rostral migratory stream (RMS) from the subventricular zone (SVZ). Serotonergic fibers (red) originate from the dorsal and medial raphe nuclei in the brain stem and target adult-born cells in the SVZ (1), RMS (2), and OB (3). OC: olfactory cortex; LV: lateral ventricle. (C) Upper panel: close-up of the three framed areas in B. Left: In the SVZ, radial glia-like cells (B cells) give rise to transient amplifying cells (C cells), which then generate neuroblasts (A cells). Middle: in the RMS, neuroblasts migrate along the glial sheets to the OB. After arrival, they switch to radial migration. Right: In the OB, neuroblasts mature to become granule (GCs) and juxtaglomerular (JGCs) cells. EPL: External plexiform layer; GCL: granule cell layer; GL: glomerular layer; MCL: mitral cell layer; ONL: olfactory nerve layer. Lower panel: serotonin (5-HT) receptors involved in serotonergic signaling in the respective region.

<b>Figure 1: Region-specific effects of serotonergic signaling on adult neurogenesis.</b>
(A) Scheme of the mouse head showing the location of the nasal cavity, olfactory epithelium, olfactory bulb (OB), and the cortex. (B) Magnification of the area, delineated by the broken line in A, showing olfactory sensory neurons (OSNs, orange) within the olfactory epithelium projecting to the OB and terminating in the glomeruli. Adult-born cells (green) arrive in the OB after migration along the rostral migratory stream (RMS) from the subventricular zone (SVZ). Serotonergic fibers (red) originate from the dorsal and medial raphe nuclei in the brain stem and target adult-born cells in the SVZ (1), RMS (2), and OB (3). OC: olfactory cortex; LV: lateral ventricle. (C) Upper panel: close-up of the three framed areas in B. Left: In the SVZ, radial glia-like cells (B cells) give rise to transient amplifying cells (C cells), which then generate neuroblasts (A cells). Middle: in the RMS, neuroblasts migrate along the glial sheets to the OB. After arrival, they switch to radial migration. Right: In the OB, neuroblasts mature to become granule (GCs) and juxtaglomerular (JGCs) cells. EPL: External plexiform layer; GCL: granule cell layer; GL: glomerular layer; MCL: mitral cell layer; ONL: olfactory nerve layer. Lower panel: serotonin (5-HT) receptors involved in serotonergic signaling in the respective region.