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  Indian J Med Microbiol
 

Figure 1: Representative images of the Aβ oligomer-induced activation of NMDAR through insertion of the oligomers in the lipid bilayer and its consequent destabilization, sensed by the NMDAR due to their mechanosensitivity. The lysophosphatidylcholine (cone shape) insertion neutralizes the oligomer-induced activation of the NMDAR, due to the opposing force exerted by the lipids which effectively inhibits the mechanical signal generated by the oligomers. By contrast, the arachidonic acid (inverted cone shape) insertion, does not have an additive effect with the oligomers as the oligomers are already “mechanosensitively” activated, suggesting the same mechanism of action. Aβ: Amyloid β; NMDAR: N-methyl-D-aspartate receptors.

<b>Figure 1: Representative images of the Aβ oligomer-induced activation of NMDAR through insertion of the oligomers in the lipid bilayer and its consequent destabilization, sensed by the NMDAR due to their mechanosensitivity.</b>
The lysophosphatidylcholine (cone shape) insertion neutralizes the oligomer-induced activation of the NMDAR, due to the opposing force exerted by the lipids which effectively inhibits the mechanical signal generated by the oligomers. By contrast, the arachidonic acid (inverted cone shape) insertion, does not have an additive effect with the oligomers as the oligomers are already “mechanosensitively” activated, suggesting the same mechanism of action. Aβ: Amyloid β; NMDAR: N-methyl-D-aspartate receptors.