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  Indian J Med Microbiol
 

Figure 1: Cell replacement therapy shows promise as an emerging retinal therapeutic that can help the growth of global market for retinal therapeutics. (A) Global market value of regenerative medicine versus retinal therapeutics projected until 2026 (Data gathered from (No author listed, 2019)). (B) Schematic of the mature retina consisting of (from right to left): the retinal pigment epithelium (RPE), outer nuclear layer (ONL) containing photoreceptor cells, inner nuclear layer (INL) containing horizontal, bipolar and amacrine cells, and ganglion cell layer (GCL) containing ganglion cells. (C) Micro-optic stalk (μOS) device bonded to a glass microscope slide with dime for scale (Diameter = 17.91 mm), reproduced with permission from Zhang et al. (2020). (D) Brightfield image of the device design to illustrate micrometer scale and compartmentalized geometry (scale bar: 100 μm). (E) Confocal image illustrating the heterogeneous composition of clusters of retinal neuroblasts using RFP+ to identify neuronal precursor cells (NPCs) and GFP+ to denote glial precursor cells (GCPs) (scale bar: 50 μm). Borrowed with permission from Pena et al. (2019). (F) Brightfield image of motile retinal neuroblasts migrating collectively within the μOS device, arrow indicates single, non-motile retinal neuroblast (scale bar: 30 μm), reproduced with permission from Zhang et al. (2020).

<b>Figure 1: Cell replacement therapy shows promise as an emerging retinal therapeutic that can help the growth of global market for retinal therapeutics.</b>
(A) Global market value of regenerative medicine versus retinal therapeutics projected until 2026 (Data gathered from (No author listed, 2019)). (B) Schematic of the mature retina consisting of (from right to left): the retinal pigment epithelium (RPE), outer nuclear layer (ONL) containing photoreceptor cells, inner nuclear layer (INL) containing horizontal, bipolar and amacrine cells, and ganglion cell layer (GCL) containing ganglion cells. (C) Micro-optic stalk (μOS) device bonded to a glass microscope slide with dime for scale (Diameter = 17.91 mm), reproduced with permission from Zhang et al. (2020). (D) Brightfield image of the device design to illustrate micrometer scale and compartmentalized geometry (scale bar: 100 μm). (E) Confocal image illustrating the heterogeneous composition of clusters of retinal neuroblasts using RFP<sup>+</sup> to identify neuronal precursor cells (NPCs) and GFP<sup>+</sup> to denote glial precursor cells (GCPs) (scale bar: 50 μm). Borrowed with permission from Pena et al. (2019). (F) Brightfield image of motile retinal neuroblasts migrating collectively within the μOS device, arrow indicates single, non-motile retinal neuroblast (scale bar: 30 μm), reproduced with permission from Zhang et al. (2020).