Figure 3: Effect of enriched environment on the learning and memory impairment of offspring exposed to sevoflurane inhalation in the second trimester of pregnancy. (A) The activity track of offspring rats in the Morris water maze spatial exploration test. The movement track of the Sev group was the most complex. The Sev + EE group was improved compared with the Sev group. (B–D) Quantitative results of swimming speed (B), escape latency (C), and path length to platform (D) in the navigation test. (E, F) Quantitative results of duration in target quadrant (E) and number of platform crossings (F) in the spatial exploration test. Data are shown as mean ± SD (eight litters/group, three offspring within each litter as replicates). *P < 0.05, vs. control (C) group; #P < 0.05, vs. sevoflurane (Sev) group (one-way analysis of variance followed by least significant difference post hoc test). EE: Environmental enrichment group; Sev + EE: sevoflurane + environmental enrichment.