Figure 1: Lithium promotes recovery of motor function and tissue repair in rats with spinal cord injury (SCI). Sham group: No spinal cord injury or treatment; SCI group: spinal cord injury only; LiCl group: lithium treatment after spinal cord injury. (A) Basso, Beattie, Breshman (BBB) Locomotor Rating Scale scores. (B) Inclined plane test. (C) Representative hematoxylin-eosin staining of spinal cord sections 7 days after surgery. The neuronal damage in the LiCl group was more severe than that in the sham group, but less severe than that in the SCI group. Black arrows indicate ruptured cells. Scale bars: 500 μm (upper), 100 μm (lower). (D) Quantification of the ratio of the area of cavity space to the area of the lesion center 7 days after surgery. (E) Representative images of Nissl staining of spinal cord sections 7 days after surgery. The number of neurons in the injured area was lower in the LiCl group than in the sham group, but higher than in the SCI group. Black arrows indicate neurons with irregular morphology. Scale bars: 100 μm. (F) The number of Nissl-positive cells per 0.05 mm2 7 days after surgery. Data are shown as mean ± SD (n = 6). *P < 0.05, vs. sham group; #P < 0.05, vs. SCI group (one-way analysis of variance followed by the least significant difference test). LiCl: Lithium chloride; SCI: spinal cord injury.