Figure 2: Differentially expressed genes 2 weeks after SCI in zebrafish. (A) Volcano plot of DEGs between control and injury groups. We screened DEGs based on FDR < 0.001 and |log2FoldChange| > 0.5. The green, red and black points represent down-regulated genes, up-regulated genes, and no significant difference, respectively. (B) Heat map of the top 50 up-regulated and down-regulated DHEGs. The hierarchical clustering heat map of DHEGs was screened based on |log2FoldChange| > 0.5 and FDR < 0.001. The top 50 genes were strongly expressed and were also DHEGs in the injury group. Green indicates down-regulation and red indicates up-regulation. The two columns on the left are the control samples. The two columns on the right are the injury samples. DEG: Differentially expressed gene; DHEG: differentially higher expressed gene; FDR: false discovery rate; SCI: spinal cord injury.